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Guotai Junan's annual strategy for innovative drugs in 2025: innovative pharmaceutical companies have accelerated into the harvest period, and the valuation has been at a historical low in the past five years. Guotai Junan said that the centralized purchasing policy has become stable, mature and normalized, and the marginal impact has weakened. Innovative drugs have gained policy inclination in the medical insurance negotiation. In the past two years, the policy has continued to promote pharmaceutical innovation, and the top-level design and local supporting chain support the development of innovative drugs. Commercial insurance is expected to bring new growth momentum to China's pharmaceutical market, and the overall industry trend is upward. At present, the trend of innovative drug industry is improving, the supply continues to accelerate, and a number of domestic innovative drugs are approved soon, which is expected to drive a new round of heavy volume. At the same time, the commercialization has achieved remarkable results and has occupied a dominant position in some sub-sectors. Pharma's performance continued to differentiate, and innovative drugs and just-needed drugs performed well. Biotech commercialization continues to increase, per capita yield continues to increase, the node of turning losses is approaching, and innovation ushers in the harvest period. Horizontal comparison: compared with overseas peers, the overall valuation of domestic innovative pharmaceutical companies is in a historically low range; Vertical comparison: the valuation of SW- pharmaceutical biology and SW- chemical preparations is at a historical low in the past five years, and it is expected that the valuation of subsequent sectors will pick up.More than 700 listed companies have announced the replacement of the audit institutions in 2024. According to incomplete statistics, since the beginning of this year, the number of listed companies planning to replace the accounting firms in 2024 has exceeded 700. Among them, the number of listed companies that intend to change accounting firms in October and November is 248 and 200 respectively. Looking back at the "exchange tide", three phenomena stand out: First, in order to improve the quality and ability of capital market intermediaries, the supervision of accounting firms by the regulatory authorities has been significantly enhanced. Based on the principle of prudence, listed companies collectively cancel the contract with the "problem institute"; Second, under the heavy penalty, more and more accountants choose to change their firms to practice, while listed companies choose to change their firms instead of accountants; Third, listed companies employ audit institutions through competitive negotiation, public bidding, invitation bidding, etc. In the bidding process, in order to attract more customers and increase the signing rate, the phenomenon of audit institutions reducing prices has increased. (Securities Daily)Non-bank deposit self-discipline initiative has landed, and bank financial management has welcomed "three changes". "Non-bank deposit self-discipline initiative involves a large scale of deposits, and some banks have begun to rectify. For the banking industry, the overall advantages outweigh the disadvantages. On the one hand, some configurable high-yield assets are gone; On the other hand, self-regulatory initiatives are beneficial to the bond market, and bond assets are an important direction for bank financial allocation. The most important thing is that in terms of risk-return characteristics, bank wealth management products are similar to interbank deposits, and it is expected that a large amount of funds will flow into the bank wealth management market from the interbank deposit market. " On December 10, a person from a financial company of a city commercial bank in the southern region bluntly told reporters.

One case of pre-application for residential land in Fengtai District, Beijing, with an initial total price of 4.008 billion yuan. According to official website of Beijing Municipal Planning and Natural Resources Committee, one case of pre-application for residential land in Fengtai District, Beijing, with an initial total price of 4.008 billion yuan. This plot is plot No.056 [2024], namely plot FT00-2404-0005 of the reconstruction project of the cold storage in the southwest suburb of Fengtai District, Beijing, with a land area of 27,422.21 square meters and a planned construction area of 69,104 square meters. The pre-application for this plot will be accepted from December 9, 2024 to January 7, 2025.Eight people were killed when the Israeli army attacked a house in the central part of Gaza, and eight people were killed and many others were injured when the Israeli army bombed a house in Nuseilet refugee camp in the central part of Gaza on the evening of 10th local time.GM will withdraw from the driverless taxi business, and the Cruise self-driving car division of GM will withdraw from the driverless taxi business. According to a statement on Tuesday, Cruise and GM's technical team will be combined to focus on developing autonomous driving and advanced driver safety technology for GM's future sales models. GM said that it will no longer provide funds for the development of self-driving taxis "considering the large amount of time and resources needed to expand its business scale and the increasingly fierce competition in the self-driving taxi market". The company said that giving up the development of self-driving taxis will save it more than $1 billion in annual costs.

Australia's S&P/ASX200 index opened down 12.60 points, or 0.15%, at 8380.4 points on Wednesday, December 11th.NVIDIA's market value evaporated by 660 billion yuan overnight. On December 10th, local time, the three major US stock indexes collectively closed down, with the Dow down 0.35%, the Nasdaq down 0.25% and the S&P 500 index down 0.30%. Among them, NVIDIA fell by 2.69%, and its market value evaporated by 91.593 billion US dollars (about 664.047 billion yuan) overnight.AI can solve partial differential equations thousands of times faster than before, and partial differential equations play an important role in engineering and science. In a recent study, scientists from Johns Hopkins University in the United States have developed a new artificial intelligence (AI) model called "Differential Mapping Operator Learning" (DIMON), which can solve complex partial differential equations on personal computers, thousands of times faster than before, and is expected to "show its talents" in the fields of aerospace, automobiles and medicine. Related papers were published in the journal Nature Computational Science published on the 9th.